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trichlorotrifluoromethane vs 111Trichloroethane

To: "Erickson, Philip" <philip.erickson@Agouron.COM>,
Subject: trichlorotrifluoromethane vs 111Trichloroethane
From: snyler <marc@animalfirm.com>
Date: Fri, 6 Apr 2001 17:07:28 -0500
Erickson, Philip wrote

>trichlorotrifluoromethane???????
>Six substituents on one carbon, I don't think so?
>Carbon is tetravalent => 4 max.
>BTW
Too many syllables, maybe? as it turns out 111Trichloroethane is the 
dry-cleaning fluid type solvent that I lived with for so long  An old 
boss called it "safety solvent...safe to bathe in!"...data below:

1,1,1-trichloroethane

CATEGORY: Chlorinated hydrocarbon 
 USE 

 Domestic: It is an ingredient in consumer products such as household 
cleaners, glues, and aerosol sprays. 

Agricultural: 

Industrial: Solvent and degreasing agent in industry. Recently found wide 
use as a substitute for carbon tetrachloride (US EPA). 

 ACUTE TOXICITY 
Effects reported in humans due to acute (short-term) inhalation exposure 
to 1,1,1-trichloroethane include hypotension, mild hepatic effects, and 
central nervous system (CNS) depression. Cardiac
arrhythmia and respiratory arrest may result from the depression of the 
CNS. Symptoms of acute inhalation exposure include dizziness,nausea, 
vomiting, diarrhea, loss of consciousness, and decreased blood pressure 
(US EPA). 

CHRONIC TOXICITY 
After chronic (long-term) inhalation exposure to1,1,1-trichloroethane, 
some liver damage was observed in mice and ventricular arrhythmia in 
humans (US EPA).  Carcinogenic: US EPA Classification: Group D (not 
classifiable as to
human carcinogenicity), based on no reported human data and inadequate 
animal data. 
Mutagenic: 
Teratogenic: 
Reproductive effects: No information is available on the reproductive or 
developmental effects of 1,1,1-trichloroethane in humans. Several studies 
in several animal species found no evidence that the chemical has 
reproductive effects. 
FATE IN THE ENVIRONMENT 
The estimated half-life for methylchloroform in air is 2.2 to 4.8
years. Evaporation and leaching are the major routes of removal from
soils. Volatilisation into the atmosphere is the main route of removal
 from water. The half-life in water ranges from hours to weeks. Due
 to the large output and slow degradation of the chemical, the
atmospheric concentration is increasing by 4.8 -17% a year (US EPA). 

ACTION ON ANIMALS 
Methylchloroform has moderate acute toxicity to aquatic organisms. LC50 
and EC50 values for methylchloroform in aquatic organisms range from 
approximately 30 to 130 mg/L; these values exceed measured concentration 
in untreated ground or surface waters by several orders of magnitude (US 
EPA). 

ACTION ON PLANTS 

 REFERENCES 
US EPA. http://www.epa.gov/ttn/uatw/hlthef/trichlor.html,
http://www.epa.gov/opptintr/chemfact/s_methch.txt 
Worksafe.
 http://www.worksafe.gov.au/worksafe/exp/09/111Trichloroethane.htm


==========================================================================
Marc Tyler
Designer,
Animal Firm
830-324-6578
www.animalfirm.com

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